National Institutes of Health (NIH)

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Applicant organizations may submit one application per UM1 application.

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH.

To accomplish the stated overarching goal, this FOA will provide support to recipients of Clinical and Translational Science Awards (CTSA) for creative educational activities with a primary focus on research experiences designed to ensure that the participants receive exposure to the scientific and operational principles underlying each step of the translational process so that they can apply these principles to clinical and translational science research areas such as: 1) pre-clinical research, 2) clinical research, 3) clinical implementation, and 4) public health.

• Research Experiences

Amount Description

The maximum budget is $100,000 direct costs/year. The budget request for a given application needs to be adequately justified and reflect the actual needs of the proposed project. Yearly fluctuations in the project workload should be reflected in the requested budget.

The scope of the proposed project should determine the project period. The maximum project period is 5 years.

Eligibility Requirements

NCATS solicits the submission of one set of companion applications. With this solicitation for the R25 application, a separate, companion FOA solicits applications for a required UM1 (PAR-21-293: Clinical and Translational Science Award). The UM1 and initial R25 applications must be submitted concurrently; an R25 application without the required companion UM1 application will not be reviewed. The R25 application will only be awarded if the UM1 application is awarded. Resubmission of an R25 without the required UM1 will be allowed only if the UM1 application is awarded.

The sponsoring institution must assure support for the proposed program. Appropriate institutional commitment to the program includes the provision of adequate staff, facilities, and educational resources that can contribute to the planned program

The PD/PI should be an established investigator in the scientific area in which the application is targeted and capable of providing both administrative and scientific leadership to the development and implementation of the proposed program. The PD/PI will be expected to monitor and assess the program and submit all documents and reports as required.

The UM1 PD(s)/PI(s) may not be a PD(s)/PI(s) on the R25 award.

NCATS solicits the submission of one set of companion applications. With this solicitation for the R25 application, a separate, companion FOA solicits applications for a required UM1 (PAR-21-293: Clinical and Translational Science Award). The UM1 and initial R25 applications must be submitted concurrently; an R25 application without the required companion UM1 application will not be reviewed. The R25 application will only be awarded if the UM1 application is awarded. Resubmission of an R25 without the required UM1 will be allowed only if the UM1 application is awarded. The sponsoring institution must assure support for the proposed program. Appropriate institutional commitment to the program includes the provision of adequate staff, facilities, and educational resources that can contribute to the planned program

• Applicants lacking the following will be considered as not responsive. Nonresponsive applications will not be reviewed.

• New applications that are not submitted as part of the companion and required UM1 PAR-21-293 Clinical and Translational Science Award (UM1 Clinical Trial Optional).

• Resubmission of R25 Research Education applications that are not linked to a funded UM1.

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NIGMS will accept only one MSTP application per institution.

The goal of the Medical Scientist Training Program (MSTP) is to develop a diverse pool of well-trained clinician-scientist leaders available to address the nation’s biomedical research needs. Specifically, this funding announcement provides support to eligible, domestic organizations to develop and implement effective, evidence-informed approaches to dual-degree training and mentoring that will keep pace with the rapid evolution of the biomedical research enterprise and lead to the completion of both a clinical degree (for example, M.D., D.O., D.V.M., D.D.S., Pharm.D., etc.) and a research doctorate degree (Ph.D.).  

With the dual qualifications of a rigorous scientist and clinician, graduates will be equipped with the skills to develop research programs that accelerate the translation of research advances to the understanding, detection, treatment, and prevention of human disease, and to lead the advancement of biomedical research.  Areas of particular importance to NIGMS are optimizing training efficiency, fostering the persistence of alumni in research careers, and enhancing the diversity of the clinician-scientist workforce.  NIGMS expects that the proposed research training program will incorporate didactic, research, mentoring and career development elements to prepare trainees for careers that will have a significant impact on the health-related research needs of the nation.

This Notice of Funding Opportunity (NOFO) does not allow appointed Trainees to lead an independent clinical trial, but does allow them to obtain research experience in a clinical trial led by a mentor or co-mentor.

NIGMS allows multiple institutions to participate in a single MSTP application, where this may further advance the goals of the program.  A single contact institution would receive and administer the award.

The sponsoring institution must assure support for the proposed program. Appropriate institutional commitment to the program should be detailed in the Organizational Support Letter in the Letters of Support attachment. See the application instructions for the required Letters of Support instructions in Section IV.

As described in the instructions for the Training Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) in Section IV.2 below, NIGMS encourages multiple PDs/PIs, particularly when each brings a unique perspective and skill set that will enhance training. Note the following:

• To provide research training leadership for the program, at least one of the training PDs/PIs should have a record of using rigorous and transparent methods in experimental design, data collection, analysis, and reporting in a biomedical research field applicable to the program.
• Additional PDs/PIs may be included to strengthen the expertise of the PD/PI team. Examples include individuals such as program directors who regularly interact with students, or individuals with expertise in education, relevant social sciences, program evaluation, mentoring, or university administration. 

Any of the PDs/PIs may serve as the contact PD/PI. The contact PD/PI is expected to have a full-time appointment at the applicant organization unless extremely well-justified. If the full-time status of the contact PD/PI changes after the award, the organization must obtain prior program approval to appoint a new PD/PI or request a deviation from the full-time rule. The PD(s)/PI(s) will be responsible for:

• The overall direction, management, administration, and evaluation of the program.
• The day-to-day administration of the program, including direct involvement with trainees.
• The selection and appointment of trainees to the research training program.
• The selection of faculty mentors for the program, assessment of mentor performance, and ensuring the program deals appropriately with substandard mentor performance.
• Monitoring and assessing the program and submitting all documents and reports as required.
• Appointing members of the Advisory Committee (when applicable) and implementing their guidance as appropriate.

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Only one application per Institution (normally identified by having a unique entity identifier (UEI) or NIH IPH number) is allowed; however, that institution may also participate as partner via a sub-award or associate program through applications submitted by other institutions.

NIEHS invites applications for cooperative agreements to support the development and delivery of model programs for the training and education of workers engaged in activities related to hazardous materials and waste generation, removal, containment, transportation, and emergency response. This funding opportunity announcement aims to use safety and health training to prevent and reduce work-related harm. The training programs will provide skills and knowledge to workers on how best to identify and protect themselves and their communities from exposure to hazardous materials encountered during hazardous waste operations, hazardous materials transportation, environmental restoration of contaminated facilities, and emergency response. A variety of industry sites, such as those involved with hazardous waste cleanup, remedial action, and transportation-related emergency response may pose severe health and safety concerns to workers and the surrounding communities. These sites contain many hazardous substances, sometimes unknown, and a site maybe uncontrolled. A major goal of the Worker Training Program (WTP) is to support institutional competency-building for the development and delivery of model training and education programs.

Renewal application budgets are not limited but need to reflect the actual needs of the proposed project.  A new applicant that has never received funding under previous announcements may request a budget for direct costs of up to $700,000 for the first year.

Indirect Costs (also known as Facilities & Administrative [F&A] Costs) are reimbursed at 8% of modified total direct costs.

Limit:1 // SF-Wung (College of Nursing)

One application per institution (normally identified by having a unique DUNS number or NIH IPF number) is allowed. This FOA seeks to support programs that include innovative approaches to enhance biomedical engineering (BME) designeducation to ensure a future workforce that can meet the nation’s needs in biomedical research and healthcare technologies.

Applications are encouraged from institutions that propose to establish new or to enhance existing team-based design courses orprograms in undergraduate biomedical engineering departments or other degree-granting programs with biomedical engineeringtracks/minors. This FOA targets the education of undergraduate biomedical engineering/bioengineering students in a team-basedenvironment. Health equity and universal design topics must be integrated throughout the educational activities. While current bestpractices such as multidisciplinary/interdisciplinary education, introduction to the regulatory pathway and other issues related tothe commercialization of medical devices, and clinical immersion remain encouraged components of a strong BME program, thisFOA also challenges institutions to propose other novel, innovative and/or ground-breaking activities that can form the basis of thenext generation of biomedical engineering design education.

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The purpose of this Centers program is to bring together basic and clinical investigators to enhance communication, multidisciplinary collaboration, and effectiveness of ongoing research in Diabetes Research Center topic areas. By providing shared access to specialized technical resources (research cores) and supporting a Pilot and Feasibility Program (P&F), DRCs are intended to create an environment that provides the capability for accomplishments greater than those that would be possible by individual research project grant support alone. New Center programs that bring in diverse perspectives, propose unique scientific themes, or provide innovative resources are encouraged. Emphasis will be placed on Center programs that propose enhanced synergies with other NIDDK-funded programs as well as providing a rich mentoring environment for future diabetes researchers.

This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. 

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This Funding Opportunity Announcement (FOA) is designed to support highly integrated research teams of three to six Program Directors/Principal Investigators (PDs/PIs) to address ambitious and challenging research questions that are within the mission of NIGMS. Project goals should not be achievable with a collection of individual efforts or projects. Collaborative program teams are expected to accomplish goals that require considerable synergy and managed team interactions. Teams are encouraged to consider far-reaching objectives that will produce major advances in their fields.

This FOA is not intended for applications that are mainly focused on the creation, expansion, and/or maintenance of community resources, creation of new technologies, or infrastructure development.

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The PRINT program aims to transform organ biofabrication by leveraging recent advances in 3D bioprinting, cell manufacturing, biomaterials, modeling, and tissue engineering. The PRINT program will assemble the necessary tools to facilitate production from a human cell source to a patient matched biofabricated organ to restore at least 40% normal organ function as demonstrated in a large animal model. 

Areas of Interest:

• Technical Area 1 (TA1): Generation of all necessary organ cell types (Phase I)
• Technical Area 2 (TA2): Large scale manufacturing of organ cell types (Phase I & II)
• Technical Area 3 (TA3): Organ Biofabrication and in vivo testing (Phase I and II)

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The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The overarching goal of this R25 program is to support educational activities that encourage individuals from diverse backgrounds, including those from groups underrepresented in the biomedical and behavioral sciences, to pursue further studies or careers in research.
To accomplish the stated over-arching goal, this FOA will support educational activities with a primary focus on:

• Courses for Skills Development
• Research Experiences

The ESTEEMED program is designed to foster the development of undergraduate freshmen and sophomores from diverse backgrounds to pursue further studies and careers in bioengineering or STEM fields relevant to NIBIB’s scientific mission. Applications are encouraged to propose integrated educational activities that include 3 elements: a summer bridge program for incoming freshmen, and in the freshman and sophomore years, academic year activities and summer research experiences. The ESTEEMED program is intended to expose students to bioengineering research early in their college careers while also providing students didactic, mentoring and career development opportunities. This will prepare students to join, in their junior and senior years, an honors program that promotes STEM and entrance into a Ph.D. program. The ultimate goal is for the participants to pursue a doctoral degree and a subsequent research career in bioengineering or NIBIB-relevant field.

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Only two applications per institution (normally identified by having a Unique Entity Identifier (UEI) number or NIH IPF number) are allowed.

The NIH Director's Early Independence Award supports rigorous and promising investigators who wish to pursue independent research soon after completion of their terminal doctoral degree or post-graduate clinical training, thereby forgoing the traditional post-doctoral training period and accelerating their entry into an independent research career. To support innovative and novel research across the vast NIH mission, individuals from diverse backgrounds (including those from underrepresented groups; see Notice of NIH’s Interest in Diversity) and from the full spectrum of eligible institutions in all geographic locations are encouraged to apply. Applications in all topics relevant to the broad mission of NIH are welcome, including, but not limited to, topics in the behavioral, social, biomedical, applied, and formal sciences and topics that may involve basic, translational, or clinical research. The NIH Director's Early Independence Award is a component of the High-Risk, High-Reward Research program of the NIH Common Fund.

Requirements:

• Single PD/PI: Only single PD/PI applications are allowed. Multiple PD/PIs applications will not be accepted. Only the PD/PI may be listed as a Senior/Key Person and provide a Biographical Sketch.
• Citizenship: U.S. citizenship is not required. For non-U.S. citizens, the applicant institution is responsible for ensuring the PD/PI's U.S. visa status will allow them to conduct the proposed research at the applicant institution for the entire project period.
• Degree Receipt Date: The receipt date of the PD/PI’s terminal doctoral degree or end of post-graduate clinical training must be between May 1, 2023, and September 30, 2025. The degree receipt date is that which appears on the official transcript for the degree. The end of post-graduate clinical training includes residency and fellowship periods. At the time of award, either:

1. The PD/PI must have received a PhD, MD, DO, DC, DDS, DVM, OD, DPM, ScD, EngD, DrPH, DNSc, ND (Doctor of Naturopathy), PharmD, DSW, PsyD, or equivalent doctoral degree from an accredited domestic or foreign institution (it is the responsibility of the sponsoring institution to determine if a foreign doctoral degree is equivalent).
2. Or an authorized official of the degree-granting or training institution must certify that all degree requirements have been met and that the receipt date of the degree (as will appear on the transcript) will be before September 30, 2025. An authorized official of the host institution must certify that the PD/PI will be able to conduct independent research at the institution at the time of the project start date.

• Post-doctoral Experience: The PD/PI must not have served as a post-doctoral fellow for more than 12 months following a previous, non-terminal doctoral degree (this only applies to PD/PIs with multiple doctoral degrees who served in a 12+ month post-doctoral fellowship before their terminal degree).
• Level of Effort: In the first and second years of the project period, the PD/PI must commit at least 9.6 person-months of effort to the Early Independence Award project each year (80% effort per year). In years 3-5 of the project period, the PD/PI may reduce their effort on the Early Independence Award project but must still conduct at least 9.6 person-months of general independent research each year (80% effort per year). General independent research includes the effort spent on the Early Independence Award project and any other independent research projects the PD/PI is working on.
• Non-independence at Time of Application: Individuals are eligible only if they do not have research independence at the time of application submission. Research non-independence is defined functionally rather than by position title and must have all the following characteristics:
  1. The PD/PI's current research agenda is set through concurrence with mentors.
  2. The PD/PI's research is funded primarily through support to other investigators (mentored fellowships such as NIH F31 or F32 Fellowships or NSF Graduate Research Fellowships do not preclude eligibility).
  3. The PD/PI does not have any space assigned directly by the institution for the conduct of their research.
  4. The PD/PI cannot apply for an NIH R01 grant without a special waiver or exemption from the institution according to institutional policy.

Though PD/PIs must not be functionally independent at the time of application submission, they may become functionally independent prior to time of award and still retain eligibility.

• Independent Research Position: An independent research position at a host institution is required, and the PD/PI must be able to begin independent research by the project start date. The position need not be permanent or tenure-track and may be contingent upon receipt of the Early Independence Award. Prospective PD/PIs should contact appropriate institutional leaders to seek an appointment to an independent research position. Alternatively, institutions may actively recruit eligible scientists to apply for support through this initiative. In either case, the institution is expected to provide substantial support to the PD/PI as detailed in the Facilities & Other Resources section. To foster independence, PD/PIs may benefit from being hosted by an institution at which they have not previously studied or trained.
• Career Awards: PD/PIs may apply for a research career development (K) award and DP5 at the same time, but NIH policy prohibits scientific overlap. A PD/PI may not hold a DP5 and career development award concurrently: The career development award must be relinquished to receive the DP5.
• Site Visit: NIH staff will conduct a one-time site visit at the end of the first year to assess the PD/PI's progress and to ensure they are receiving the institutional resources and support outlined in the application. NIH staff will meet with the PD/PI, lab personnel, mentors, faculty, and institutional leadership. Failure to provide independence and/or support may lead to NIH actions, including reduction of funds.

Awards will be for up to $250,000 in direct costs per year, plus applicable Facilities and Administrative (F&A) costs.

The project period is limited to five years.

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Only one application per institution (identified by having a unique NIH IPF number) is allowed.

The objective of this Notice of Funding Opportunity (NOFO) is to solicit applications to conduct institutional climate assessments using validated survey instruments and to develop action plans for positive change in the recruitment, hiring, retention, and advancement of faculty, including those from groups underrepresented in biomedical and behavioral research (see NIH Interest in Diversity).

The plans for self-studies should lead to institutional culture change by identifying perceptions, attitudes, and concerns, about, for example, inequities, micro-aggressions, institutional racism, and bias. The self-studies should provide a foundation for the development of an action plan to enhance diversity, equity, inclusion, and accessibility (DEIA) outcomes in the recruitment, hiring, retention, and advancement of faculty.

Components of Participating Organizations:
National Institute of Dental and Craniofacial Research (NIDCR)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
National Institute on Drug Abuse (NIDA)
National Institute of General Medical Sciences (NIGMS)
National Institute of Mental Health (NIMH)
National Institute of Nursing Research (NINR)
National Institute on Minority Health and Health Disparities (NIMHD)
National Cancer Institute (NCI)