National Institutes of Health (NIH)

NIDCD Early Career Research (ECR) Award (R21 Clinical Trial Optional)

The NIDCD Early Career Research (ECR) Award (R21) is intended to support both basic and clinical research from scientists who are beginning to establish an independent research career. It cannot be used for thesis or dissertation research. The research must be focused on one or more of the areas within the biomedical and behavioral scientific mission of the NIDCD: hearing, balance, smell, taste, voice, speech, or language. The NIDCD ECR Award R21 grant mechanism supports different types of projects including secondary analysis of existing data; small, self-contained research projects; development of research methodology; translational research; outcomes research; and development of new research technology. Irrespective of the type of project, the intent of the NIDCD ECR Award R21 is for the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) to obtain sufficient preliminary data for a subsequent R01 application.

Only one NIDCD ECR Award (R21) application may be submitted by a PD/PI per due date. PD/PIs who successfully obtained an NIDCD Small Grant award are ineligible for an NIDCD ECR Award (R21).

Applicants may not submit an NIDCD R01, R15 or R21 application for the same review cycle that the NIDCD ECR Award application is submitted. In such cases, the NIDCD ECR Award R21 application will be withdrawn.
External Deadline
01/27/2025 (Anticipated)

Supporting Talented Early Career Researchers in Genomics (R01 Clinical Trial Optional)

This Funding Opportunity Announcement is intended to identify and support research projects by exceptionally promising Early Stage Investigators with a long-term career interest in pursuing innovative research in genomics. This opportunity is open to research in all areas relevant to the mission of NHGRI, including genomic sciences, genomic medicine, genomic data science, and ethical, legal, and social implications of genomics.

The PD/PI must be an NIH defined Early Stage Investigator, and this eligibility must be included in the NIH Commons record prior to the review of the application.

In addition, the PD/PI must be an independent researcher with a faculty appointment that is tenure track or equivalent (generally at the level of Assistant Professor or Research Assistant Professor), and have dedicated, independent laboratory space or access to the research resources which will allow them to conduct the research proposed in the grant application as the lead PD/PI
External Deadline
01/27/2025(Anticipated)

Notice of Special Interest: Administrative Supplements to Support Emerging Physician-Scientists to Develop Research Expertise in Diabetes, Endocrinology and Metabolic Diseases

The purpose of the NIDDK’s Division of Diabetes, Endocrinology and Metabolic Diseases (DDEMD) Administrative Supplement Program is to enable additional clinical perspectives to be brought to on-going research projects within the Division's mission and to enhance the research expertise of selected physicians.The program will provide supplementary funds to support advanced research opportunities for exceptional emerging physician-scientists (hereafter, "candidates") holding the MD or equivalent or MD/PhD degrees, and who are early in their research careers.

The supplement is intended to allow candidates to expand their research experience to help them transition beyond their clinical training to the next stage of their research careers as physician-scientists.

Administrative supplements must support work within the scope of a currently funded basic, behavioral, and/or clinical DDEMD research project. PIs of projects focused on type 1 diabetes are highly encouraged to apply given the limited numbers of new MD researchers entering this area. All applicants are strongly encouraged to discuss potential requests with the NIDDK DDEMD program director of the award for which they wish to submit a supplement application. See https://www.niddk.nih.gov/about-niddk/staff-directory/by-office/division-diabetes-endocrinology-metabolic-diseases for DDEMD program director contact information.

External Deadline
02/07/2025

NCI Cancer Moonshot Scholars Diversity Program (CMSDP) (R01 Clinical Trial Optional)

This Funding Opportunity Announcement (FOA) supports the Cancer Moonshot Scholars Diversity Program (CMSDP) and solicits R01 grant applications that propose independent research projects within the scientific mission of the National Cancer Institute (NCI). The overarching goal of the CMSDP is to increase the number of R01 Early Stage Investigators (ESIs) and enhance the diversity of the cancer research workforce, while promoting scientific advancements in cancer. Investigators from diverse backgrounds, including those from underrepresented groups (NOT-OD-20-031, Notice of NIH’s Interest in Diversity), are encouraged to work with their institutions to apply.
Opportunity ID
9f4e2192-9a95-40ca-be1c-f2f1552f7976
External Deadline
02/06/2025 (Anticipated)

NIDCR Small Grant Program for New Investigators (R03 Clinical Trial Not Allowed)

This NIDCR Small Grant Program for New Investigators supports basic and clinical research conducted by scientists who are in the early stages of establishing an independent research career in oral, dental and craniofacial research. This R03 program supports pilot or feasibility studies and developmental research projects with the intention of obtaining sufficient preliminary data for a subsequent investigator­ initiated Research Project Grant (R01) or equivalent application.

Only New Investigators who fit the criteria in this section are eligible to apply to this FOA.

New Investigators whose proposed research addresses topics of relevance to the NIDCR mission are eligible and encouraged to apply. A New Investigator is one who has not previously competed successfully for substantial, independent R01 or R01-equivalent funding from NIH. When Multiple PDs/PIs are proposed, all PDs/PIs must meet the definition of New Investigator and the eligibility criteria as defined below. Current or past recipients of the NIDCR Small Grant for New Investigators (R03) grant are eligible to apply for a second NIDCR Small Grant for New Investigators (R03), provided they are still New Investigators. New Investigator status should be valid at the time of award.

Specifically, NIDCR is excluding from consideration individuals who have received:

NIH Exploratory/Developmental Research Grant (R21) support from any NIH Institute or Center, or
More than one Small Grant for New Investigators (R03) funded by NIDCR. Any PD/PI who has already received funding for two NIDCR Small Grants for New Investigators (R03) is not eligible.
Investigators who have questions about eligibility should contact the Scientific/Research Contact listed in Section VII. Agency Contacts.

Opportunity ID
a5da07f4-64b9-43aa-8aca-d1d75de8f0f3
External Deadline
02/16/2025 (Anticipated)

NIAID and NIDDK Research Opportunities for New and "At-Risk" Investigators to Promote Workforce Diversity (R01 Clinical Trial Optional)

The purpose of this notice of funding opportunity (NOFO) is to encourage researchers from diverse backgrounds to work with their institutions to submit applications for research projects within the mission of either NIAID or NIDDK. This NOFO seeks to support either (a) a New Investigator (NI), who has not previously competed successfully for substantial, independent funding from NIH, or (b) an 'At-Risk' investigator, who had prior support as a PD/PI on a substantial independent research award and unless successful in securing a substantial research grant award in the current fiscal year, will have no substantial research grant funding in the following fiscal year.

Eligible candidates will identify with one of the two categories below:

1. New Investigator (NI)

For the purpose of this NOFO, an investigator is considered a New Investigator (NI; https://grants.nih.gov/policy/early-investigators/index.htm) if they have not competed successfully for substantial, NIH independent funding from NIH. A "substantial" research award is a research grant award excluding smaller grants that maintain Early Stage Investigator (ESI)/NI status (see full list of awards here: https://grants.nih.gov/policy/early-investigators/list-smaller-grants.htm). PD/PIs of NIH Training-Related and Mentored Career Awards are still considered New Investigators if the NIH awards are in any of the following categories: fellowships (F awards), individual or institutional career awards (K awards), and loan repayment contracts (L30, L32, L40, L50, L60). Appointees who have received support from any NIH training grants (T32, T34, T35, T90, D43) are also considered New Investigators.

OR

2. At-Risk Investigator

For the purpose of this NOFO, an investigator is considered an At-Risk Investigator if they have had prior support as a Principal Investigator on a substantial independent research award and, unless successful in securing a substantial research grant award in the current fiscal year, will have no substantial research grant funding in the following fiscal year. A "substantial" research award is a research grant award excluding smaller grants that maintain ESI/NI status

Opportunity ID
a129d9dd-dacf-45b6-8c19-f2f1552f7976
External Deadline
02/05/2025 (Anticipated)

Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed)

The Stephen I. Katz Early Stage Investigator Research Project Grant supports an innovative project that represents a change in research direction for an early stage investigator (ESI) and for which no preliminary data exist. Applications submitted to this Funding Opportunity Announcement (FOA) must not include preliminary data. Applications must include a separate attachment describing the change in research direction.

The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.
This Funding Opportunity Announcement does not accept applications proposing clinical trials.
Opportunity ID
958f40d9-3f44-4b36-bad2-d1d75de8f0f3
External Deadline
12/23/2025(Anticipated)

Small Grants for New Investigators to Promote Diversity in Health-Related Research (R21 Clinical Trial Optional)

The purpose of this Funding Opportunity Announcement (FOA) is to provide support for new investigators from diverse backgrounds, including from groups nationally underrepresented in biomedical, clinical, behavioral and social sciences research, to conduct small research projects in the scientific mission areas of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) or the National Human Genome Research Institute (NHGRI). New investigators at the time of award under this FOA will have had less than $125,000 direct costs of combined research funding (excluding NIH training and NIH career awards). This R21 will support small research projects that can be carried out in a short period of time with limited resources and seeks to facilitate transition to research independence. The R21 grant mechanism supports different types of projects including pilot and feasibility studies; secondary analysis of existing data; small, self-contained research projects; development of research methodology; and development of new research technology.

Components of Participating Organizations:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Human Genome Research Institute (NHGRI)
Opportunity ID
f9a649d9-5afb-4ed7-8a8e-d1d75de8f0f3
External Deadline
02/16/2025 (Anticipated)

NIH PAR-23-221: 2024 NIH Advancing Research Careers (ARC) Institutionally-Focused Research Education Award to Promote Diversity (UE5 - Clinical Trial Not Allowed)

No applicants   // Limit: 1 // Tickets Available: 1 

 

NIH Research Education Program supports research education activities in the mission areas of the NIH. The overarching goal of this ARC UE5 program is to support educational activities that encourage individuals from diverse backgrounds, for example those from groups underrepresented in the biomedical and behavioral sciences (see Notice of NIH's Interest in Diversity ), to pursue further studies or careers in research. The overarching goal of this UE5 program is to support educational activities that encourage individuals from diverse backgrounds, for example those from groups underrepresented in the biomedical and behavioral sciences (see Notice of NIH’s Interest in Diversity), to pursue further studies or careers in research.

To accomplish the stated over-arching goal, this NOFO will support educational activities with a primary focus on:

  • Courses for Skills Development
  • Mentoring Activities

Applications are encouraged from organizations that have:

  • Experience enhancing scientific communication and networking among early-career biomedical researchers;
  • An established record of providing professional development and networking activities for future biomedical researchers; and
  • A demonstrated commitment to enhancing the diversity of the biomedical research workforce.

The program provides support for well-designed courses for skills development and mentoring activities to prepare cohorts of ARC predoctoral F99 fellows and K00 postdoctoral scholars to transition into and succeed in mentored postdoctoral research, positioning them to advance in impactful careers in the biomedical research workforce that typically require postdoctoral training (e.g., academic research and teaching at a range of institution types, industry or government research).
Recipient organizations must provide career development and mentoring activities aligned with and appropriate for the disciplinary backgrounds and career goals of scholars supported through the ARC F99/K00 program.

Components of Participating Organizations:
National Institute of General Medical Sciences (NIGMS)
National Center for Complementary and Integrative Health (NCCIH)
Sexual and Gender Minority Research Office (SGMRO)

Internal Deadline
External Deadline
01/29/2024

NIH RFA-AG-24-013: 2023 NIA Expanding Research in AD/ADRD (ERA) Summer Research Education Program (R25 - Independent Clinical Trial Not Allowed)

Limit: 2* // Tickets Available: 1 // M. H.Witte (Surgery, Neurosurgery, and Pediatrics) 

*No more than two applications are allowed per institution. If two applications are submitted then the 2 awards must be for different target groups.
 

A major goal of the National Plan to address Alzheimer’s Disease (AD) and Alzheimer’s Disease-related Dementias (ADRD)  is to reduce the burden of AD/ADRD by accelerating research toward treatments, improving care and support for people facing these conditions now, and reducing the risk of AD/ADRD by promoting brain health. Despite this, there is a shortage of scientists conducting the wide variety of necessary innovative and interdisciplinary research projects, including basic biomedical, clinical, translational, prevention, and treatment research on AD/ADRD. This Funding Opportunity Announcement (FOA) aims to address goal G-4 of the National Institute on Aging's Strategic Directions for Research (2020-2025): “Attract and train more researchers from diverse scientific and cultural backgrounds." This will include supporting the recruitment of early-stage investigators from diverse backgrounds, including those from groups underrepresented in the biomedical and behavioral sciences, to the NIH AD/ADRD portfolio. This FOA also aims to address the lack of early exposure to high-quality, hands-on research education experiences in the AD/ADRD field, another major barrier to increasing the AD/ADRD capable workforce.

To further expand the AD/ADRD training pipeline for earlier stage students, NIA will support summer research experiences for high school students, undergraduates, or science teachers. The expectation is that such a program would incubate and develop the next generation of  early-stage investigators to pursue research careers representative of in NIA mission critical areas, namely AD/ADRD research. Proposed programs should provide authentic "open-ended", hands-on exposure to AD/ADRD research as it relates to aging as part of a comprehensive program based in sound educational practices designed to stimulate the interest and advance the knowledge base of participants. In addition to hands-on research experiences, programs are expected to include complementary educational enrichment activities that support the participants' scientific development, such as relevant workshops (e.g., scientific writing and presentation skills), journal clubs, technical laboratory coursework, and training in rigor and reproducibility. Program goals and objectives should be grounded in literature and appropriate for the educational level of the audience to be reached, including the content to be conveyed, and the intended outcome(s). Outcomes for high school students may include preparing them for undergraduate admissions and enhancing their interest in pursuing a science decree. Outcomes for college students may include: reinforcing their intent to graduate with a science degree, preparing them for graduate or medical school admissions, and/or preparing them for careers in AD/ADRD research. Support for science teachers will be limited to those programs with a clear plan for how teachers will utilize their summer experience in their teaching during the school year, such as enhancing the STEM curriculum or increasing number of STEM courses taught. 

Focus on High School Students, Undergraduates, or Science Teachers: Science education research has demonstrated that early exposure to scientific research leads to the retention of trainees in science, technology, engineering, and mathematics (STEM). The President’s Council of Advisors on Science and Technology (PCAST) specifically highlights the need for retention of trainees in STEM by involving them in contemporary, hands-on research experiences especially during the first two years of college. Summer research experiences provide important experiential learning to sustain students’ interests in STEM and medicine careers. The short-term summer experience, in contrast to a year-long experience, allows for a focused and concentrated effort on instruction, and intentionally coincides with the time of year when the target populations of this program (i.e., high school students, undergraduate college students, and science teachers) would typically have the opportunity to engage in such a research educational experience. 

For the purpose of this announcement, institutions should explain how this program will be developed in a way that will foster diversity and inclusion at their organization. As indicated below, applicants must include a Recruitment Plan to Enhance Diversity which describes the program’s proposed recruitment efforts and how the proposed plan reflects past experiences in recruiting individuals from diverse backgrounds, including those from groups underrepresented in the biomedical and behavioral sciences (see NOT-OD-20-031 for additional information on NIH's Notice of Interest in Diversity). All programs are expected to be inclusive, supportive, and safe, and to provide opportunities for participants to interact with investigators who could contribute to their growth. Applications from a variety of institutions, including those from minority serving institutions (MSIs), are  encouraged.

Applicants should consider how the developed programs can optimize participation and potentially include additional participants from outside the applicant institution, especially those in local and/or affiliated institutions. Applicants must demonstrate how this program will add significant value over existing programs at the applicant institution.

Each institution must have a unique program structure that maximizes resources, departments, and faculty at the applicant institution to address the target population. Applicants are encouraged to propose collaborations with affiliated and/or local institutions, as appropriate. Applicants are also encouraged to partner with existing NIH-funded or other federally-funded resources and programs and leverage training activities from both federal and private-sector partners including, but not limited to, the following:

Funding Type
Internal Deadline
External Deadline
05/25/2024